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WHEN to start medication?

The NICE guidelines on depression (NICE, 2004) describe a stepwise approach to the management of depression.

 

Step 5:

 Inpatient care, crisis teams

Risk to life, severe self-neglect Medication, combined treatments, ECT
Step 4:

Mental health specialists including crisis teams

Treatment-resistant, recurrent, atypical and psychotic depression, and those at significant risk Medication, complex psychological interventions, combined treatments
Step 3:

Primary care team, primary care mental health worker

Moderate or severe depression Medication, psychological interventions, social support
Step 2:

Primary care team, primary care mental health worker

Mild depression Watchful waiting, guided self-help, computerised CBT, exercise, brief psychological interventions
Step 1:

GP, practice nurse

Recognition Assessment

The stepped care model (NICE, 2004)

 

Mild Depression:

  • Antidepressants are not recommended in the initial treatment of mild depression i.e. steps 1 and 2, because the risk-benefit ratio is poor.

Moderate Depression:

  • The commencement of medication is clearly identified as part of the management of moderate depression.  Antidepressant medication is recommended to be commenced prior to any of the psychological therapies.

Severe Depression:

  • Patients who present with severe depression should be considered for a combination of antidepressant medication and individual CBT as this combination is more cost effective than either treatment on its own.

 

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WHEN to follow-up?

(Macarthur Foundation, 2004)

Initial management:

Mild depression:

  • Watchful waiting, a telephone call or consultation monthly.

Moderate depression:

  • A consultation or telephone call every 2 weeks.

Severe depression:

  • A consultation or telephone call every week.

 

Follow-up after symptom resolution:

It is important to maintain regular contact with the patient with a moderate or severe depression in order to ensure concordance with their antidepressant medication and to ensure there is no relapse of symptoms.

All patients:

Consultation or telephone call every 2-3 months following remission.

 

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WHEN to stop medication? 

(Macarthur Foundation, 2004)

Depression is often a chronic disease and continuation of antidepressants for 4-9 months after achieving remission helps to reduce relapse.

  • 40-50% of depressed patients may experience a new episode of depression within 2 years of a first episode of major depression.

  • Following recurrence of depression the relapse rate increases to 75%.

  • Long-term maintenance on antidepressants for patients with a recurrence of depression significantly reduces recurrence.

  • Many patients with a recurrence of symptoms do not seek help immediately, annual monitoring of patients with a history of depression may therefore be useful to detect early signs of relapse.

  • Clinicians should maintain a high level of suspicion when this group of patients are seen in the interim for other problems.

 

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Disclaimer

This website is intended to provide helpful and informative material on the subject of depression.
It is not intended to provide medical advice to patients.
All information in this website is the sole responsibility of Penny Louch.
 

Last updated 17 August 2008

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Copyright ©2006 Penny Louch